Game Party 2, like its predecessor, is a collection of the following party and skill games.

• Darts
• Skill Ball
• Hoop Shot
• Shuffleboard
• Ping Cup
• Trivia
• Puck Bowling
• Bean Bags
• Horseshoes
• Lawn Darts
• QB Challenge

All eleven games can be played with up to four players simultaneously, and up to 16 players can compete in a variety of tournament modes to select from. The Wii Remote is used to aim, throw, and perform other actions to simulate the real-life games. Various characters, including customized ones, can be selected to act as the player's avatar. Equipment to customize those characters can be unlocked as the game progresses.