In LEGO Indiana Jones 2: The Adventure Continues the players once again explore the Indiana Jones universe with "LEGO-fied" characters. This time the main part of the game focuses on the events of the fourth film of the series called Indiana Jones and the Kingdom of the Crystal Skull with three campaigns retelling the story in a humorous, light-hearted way similar to the other games from the LEGO series. The other three campaigns on the other hand once again turn their focus on the original three films but with different scenes and levels that can't be found in the first game.

The game itself is a third-person platform/action game where the players take control over various heroes including Indiana Jones and side-characters which mostly don't have any real name. Again each character has has different abilities, fears and weapons. While Indiana Jones has his whip to pull items out of reach or constrain enemies with, his son Mutt is a very good repairman. The characters also have different phobias (snakes, rats, spiders), each corresponding to their personalities.

Instead of providing a central hub which the characters return after each mission, this time around not only the story moves forward but also the locations. So while the game starts out at the University campus and uses it as the main hub, it eventually moves over to the dig-site in South America. After each successful mission a new part of the hub is unlocked mostly through unlocking new characters or vehicles that allow the player to get to previously unreachable territory. Since these hubs are very big, a great amount of vehicles is available to unlock the same way other characters are unlocked: finding them in the hub and paying studs for them. Studs are again collected by destroying scenery objects, building stuff and such. To that end each level again holds a great amount of secret for which different characters are needed to unlock them requiring several playthroughs of the same level to find all bonus items and complete the game 100%.

The game once again features an editor to create unique heroes from parts. In addition a level editor is now available where the player walks around the map spawning the items he needs and putting them in place with his character. The two-player co-op mode also makes his return allowing two players to play through the whole game. The second player can enter the game at any given time by pressing a button on the second controller. As opposed to the previous games, the players aren't restricted to the same area anymore. Instead they now both can move freely around. Once a character leaves the screen of the other, the view gets divided with the placement of each character-view changing all the time depending on which direction the corresponding player is moving in relation to the center of the level.