In Super Monkey Ball: Banana Blitz, you must play as either AiAi, MeeMee, Baby, or GonGon as well as two new characters: Doctor and YanYan. Your mission: to recover the golden bananas stolen by an evil pirate monkey.

Pitch and roll your wiimote to manipulate the level to roll your ball encapsulated monkey through ten worlds (eight hidden and two secret) on a quest to regain all of the golden bananas. Collect bananas to gain extra points and lives then roll yourself to the exit point to finish levels. You will need to be careful to avoid the edges, traps and gaps so your monkey can progress on his or her way.

For the first time in a monkey ball game you'll fight bosses in each world each with their own weak spot. Also, new is that each of the six monkeys now has different characteristics in the single player mode. Choose your monkey carefully as they all have their own strengths and weaknesses; some might weight more, jump better, or accelerate faster than others.

Then play in 50 party mini-games either by yourself or with up to four friends in multiplayer. Returning games from previous monkey ball titles include: Monkey Golf, Monkey Bowling, Monkey Race, Monkey Target, and Home Run Derby. Play the mini-games individually or in sequence play to see who can get the most points after playing a number of games.