Jackie Estacado returns in the sequel to The Darkness. Jackie has been able to shut away the Darkness for two years, but a sudden attack of a rival gang makes him release the dark powers in order to survive. Jackie will set on a mission to uncover the mystery of the force behind the attackers. It's also somehow connected to Jenny, his murdered girlfriend that he still loves...

Handled by a different development studio, The Darkness II has a more straightforward FPS approach than its predecessor. Jackie is now able to shoot firearms and use the Darkness simultaneously. However, the dark powers disappear once Jackie steps into the light so it's important to eliminate light sources. Jackie's dark powers are upgradable with the use of 'dark essence' which is added after each kill.

In addition to the single player campaign there's Vendetta mode for up to four players. It offers a different story told along side Jackie's and four playable characters with unique weapons and abilities.

The graphics are produced using a cel-shading technique to emulate the visuals of the graphic novel.