In Full Spectrum Warrior, you take on the role of commander of two squads of the United States military, Alpha and Bravo, as you guide them in the fictional country of Zekistan on a mission to capture or kill the terrorist Al Afad.

In this game, you don't directly control your troops. You don't take aim at a target and shoot, and you don't circle-strafe around enemies. Instead, you tell your squad what to do, and they'll do it. It's like a real-time strategy game. You can tell your two squads to do numerous things, such as hide behind a wall, take cover behind a car, lob a grenade, fire off a rocket, or attack a target. You will need to utilize both squads to be successful. For example, you can have Alpha squad hide behind a car and lay down covering fire at a target that you can't directly kill, giving Bravo squad cover so they may cross open terrain, and get into a position where they will be able to kill the enemy.

The game takes place in one location, a Middle Eastern country, that is split up into several areas. You will have to make your way through parks, an airport, city streets, and even some buildings. Throughout the country are many terrorists, all of whom are trying to kill you. You have four members on each squad; the team leader, automatic rifleman, grenadier and rifleman, each playing a unique role.

Full Spectrum Warrior supports Xbox Live, where two players can play through the single player campaign. Instead of controlling both squads, one player controls Alpha while the other controls Bravo.