Gabriel Belmont is a member of the Brotherhood of Light, a group of holy knights who serve to protect the innocent from the forces of evil. His wife Marie, recently murdered by the same evil, now lies trapped between the Earth and the Heavens. Her soul, along with many others, is neither living nor dead. Gabriel finds out that the Lords of Shadow are behind everything, and that they possess an item known as the God Mask that could bring his beloved Marie back from the dead. Together with Zobek, another member of the Brotherhood, he sets out across the ruined landscapes of Earth; filled with everything from werewolves, vampires, and undead beings, to end the Lords of Shadow destruction. Gabriel vows to do everything in his power to get his Marie back, even at the cost of falling into the darkness he seeks to destroy.