Nickelodeon Party Blast is a party game for up to four players with Nicktoons characters from Nickelodeon. Game modes are Blast, Replay, Cup Challenge and Party Play (multiplayer only). There are several game modes where characters need to complete stages through different events. The eight playable characters are Angelica, Invader Zim, Spongebob, Eliza Thornberry, Otto Rocket, Reggie Rocket and Jimmy Neutron. They come from the series Invader Zim, Jimmy Neutron, Rocket Power, Rugrats, SpongeBob SquarePants and Wild Thornberrys.

A game generally consists of several types of stages based around a mini-game with a boss at the end. There is Food Fight where characters throw food at each other in a single-screen environment, there is a squirting game called Squirt and Splash, a basketball game mixed with skating elements, Pipe Challenge where pipes need to be put together to blast rockets, a racing game and so on. There are also bonus stages with different gameplay. Stars can be earned to unlock additional cups as series of stages.