Destruction AllStars is a vehicular arena combat game for up to sixteen players online. It is a PS5 exclusive and was made available for free at launch through the PlayStation Plus program. Players wreck each other in cars in arenas filled with obstacles, ramps and pits, but can also leave the vehicle to move and fight on foot or enter a new vehicle. There are no weapons or power-ups to pick up, attacking can only be done by hitting directly.

While on foot characters can move, jump and have a barge attack as well as a breaker - an on-foot super that provides double jump, a speed boost and a strong ability unique for each of the sixteen available characters. Characters can also jump and hang on to cars, and be shaken off. Cars are not unique to a specific character. The vehicles are divided into light, medium and heavy classes.

There are four multiplayer modes. In single-player there is an Arcade mode, a Practice mode and mode where games can be customized. In single-player the game is played against bots. Using the in-game currency or real money through in-app purchases skins, emotes, vehicle emotes and shouts can be unlocked. There is a Challenge Series mode with seven challenges divided over the available game modes, with story elements and cut-scenes showing clashes between two characters. The first is available for free, but the other series can only be bought using real money. There is support for voice chat.