In LEGO Indiana Jones 2: The Adventure Continues the players once again explore the Indiana Jones universe with "LEGO-fied" characters. This time the main part of the game focuses on the events of the fourth film of the series called Indiana Jones and the Kingdom of the Crystal Skull with three campaigns retelling the story in a humorous, light-hearted way similar to the other games from the LEGO series. The other three campaigns on the other hand once again turn their focus on the original three films but with different scenes and levels that can't be found in the first game.

The game itself is a third-person platform/action game where the players take control over various heroes including Indiana Jones and side-characters which mostly don't have any real name. Again each character has has different abilities, fears and weapons. While Indiana Jones has his whip to pull items out of reach or constrain enemies with, his son Mutt is a very good repairman. The characters also have different phobias (snakes, rats, spiders), each corresponding to their personalities.