When an inter-dimensional vacuum cleaner called the Negativatron appears, Sackboy must step back into action, alongside Larry Da Vinci and The Alliance, to save Craftworld and Avalonia.

LittleBigPlanet 2 is a side-scrolling platformer like it's predecessor, once again working on three plains which the player can move between, and allowing the player to create their own levels. This sequel includes more sophisticated customization tools which allow more options for more complex user-generated content. These features include, and are not limited to, the Controlinator, which allows one to assign action triggers to buttons on the controller, as well as Sackbots, AI-controlled sack-people.